A Reliable BioFET Immunosensor for Detection of p53 Tumour Suppressor in Physiological-Like Environment
نویسندگان
چکیده
منابع مشابه
p53 tumour suppressor
Other speculated functions include1⁄4 does it really need more? Well, it seems to function in multicellular development and differentiation, too, and there’s some evidence that it’s an exonuclease. If you’re beginning to think that researchers from all areas of biology are obsessed with p53, witness the number of grant applications claiming that studies of p53 will provide a cure for cancer, ex...
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Neuroendocrine pancreatic tumours grow slower and metastasise later than ductal and acinar carcinomas. The expression of the p53 tumour suppressor gene in pancreatic neuroendocrine tumour cells is unknown. Pancreatic neuroendocrine cell lines (n = 5) and human tumour tissues (n = 19) were studied for changed p53 coding sequence, transcription, and translation. Proliferative activity of tumour c...
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The tumour suppressor CYLD is a deubiquitinase previously shown to inhibit NF-κB, MAP kinase and Wnt signalling. However, the tumour suppressing mechanisms of CYLD remain poorly understood. Here we show that loss of CYLD catalytic activity causes impaired DNA damage-induced p53 stabilization and activation in epithelial cells and sensitizes mice to chemical carcinogen-induced intestinal and ski...
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Tumour suppressor p53 has been the centre of focus of researchers trying to decipher the molecular mechanisms underlying tumourigenesis. In this review, we have summarized the critical role of p53 in tumour suppression through its effects on several cellular processes such as DNA repair, cell cycle and apoptosis. We have also discussed the role of upstream regulators which sensitize p53 to resp...
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Reprogramming somatic cells to induced pluripotent stem (iPS) cells has been accomplished by expressing pluripotency factors and oncogenes, but the low frequency and tendency to induce malignant transformation compromise the clinical utility of this powerful approach. We address both issues by investigating the mechanisms limiting reprogramming efficiency in somatic cells. Here we show that rep...
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ژورنال
عنوان ژورنال: Sensors
سال: 2020
ISSN: 1424-8220
DOI: 10.3390/s20216364